The tomato was considered poisonous in Europe for 200 years

Tomatoes arrived in Europe from South America in the 16th century and were grown as ornamental plants for two centuries, widely believed to be poisonous. The fear had some basis: tomatoes are members of the nightshade family, and their leaves and stems are indeed mildly toxic. Wealthy Europeans eating from pewter plates also noticed that tomatoes caused illness — in fact, the acidity of the fruit leached lead from the plates, causing lead poisoning. Poorer people who ate from wooden plates never had this problem. Tomatoes were adopted by southern European peasants and became central to Italian cuisine only in the 18th century.

Source: Smith, The Tomato in America (1994)